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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

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Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
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Related Experiment Video

Updated: Nov 7, 2025

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
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COVID-19 Dysautonomia.

Brent P Goodman1, Julie A Khoury1, Janis E Blair2

  • 1Department of Neurology, Mayo Clinic, Scottsdale, AZ, United States.

Frontiers in Neurology
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

COVID-19 can cause dysautonomia, a condition affecting the autonomic nervous system. This case series found varied autonomic testing results in patients experiencing symptoms like fatigue and lightheadedness after infection.

Keywords:
COVID-19POTSautonomic neuropathydysautonomiaorthostatic hypotensionpostural tachycardia syndrome

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiology

Background:

  • Dysautonomia is a condition characterized by the dysfunction of the autonomic nervous system.
  • COVID-19 has been anecdotally linked to various neurological complications.
  • The specific impact of COVID-19 on autonomic function requires further investigation.

Purpose of the Study:

  • To describe the clinical presentation and autonomic testing results of patients with dysautonomia following COVID-19 infection.
  • To identify patterns of autonomic dysfunction associated with prior SARS-CoV-2 infection.

Main Methods:

  • Retrospective case series review.
  • Inclusion of patients evaluated in an autonomic clinic with suspected dysautonomia.
  • Formal autonomic function testing, including head-up tilt table testing and sudomotor assessments.

Main Results:

  • Six patients with a history of COVID-19 infection and symptoms of dysautonomia were identified.
  • Common symptoms included postural lightheadedness, near-syncope, fatigue, and activity intolerance.
  • Autonomic testing revealed diverse findings: excessive postural tachycardia (4 patients), postural hypertension (3 patients), orthostatic hypotension (1 patient), and sudomotor impairment (1 patient).

Conclusions:

  • COVID-19 infection can be associated with a spectrum of dysautonomia.
  • Clinical features often include orthostatic intolerance, fatigue, and activity intolerance.
  • Autonomic testing results in post-COVID-19 dysautonomia are heterogeneous, with postural tachycardia syndrome being a common finding.