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Translational Orthotopic Models of Glioblastoma Multiforme

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Published on: February 17, 2023

TRP Channels in Brain Tumors.

Giorgia Chinigò^1,2, Hélène Castel^3,4, Oana Chever^3,4

¹Laboratory of Cell Physiology, Department of Life Sciences, Univ. Lille, Inserm, U1003 - PHYCEL, University of Lille, Lille, France.

Frontiers in Cell and Developmental Biology

|April 30, 2021

Summary

Transient receptor potential (TRP) channels are emerging as key players in glioblastoma (GBM) development and treatment resistance. Targeting TRP channels offers new therapeutic strategies for high-grade gliomas.

Keywords:

TRP channel brain tumor glioblastoma glioma ion channel

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Area of Science:

Neuro-oncology
Molecular Biology
Cancer Research

Background:

Malignant glioma, particularly glioblastoma (GBM), is a highly aggressive primary brain tumor with poor prognosis.
Treatment resistance in GBM is driven by tumor heterogeneity, angiogenesis, and hypoxic microenvironments, leading to recurrence.
Transient receptor potential (TRP) channels, involved in cellular responses to stimuli, are increasingly recognized for their role in cancer, including glioma.

Purpose of the Study:

To explore the potential of TRP channels as diagnostic and prognostic biomarkers in glioma.
To elucidate the mechanisms by which TRP channels influence glioma progression and treatment resistance.
To identify novel therapeutic targets within the TRP channel superfamily for high-grade glioma treatment.

Main Methods:

Review of current literature on TRP channels in glioma.
Analysis of TRP channel involvement in key cancer pathways such as proliferation, cell cycle, apoptosis, DNA repair, and migration/invasion.
Discussion of specific TRP channels (TRPC6, TRPM8, TRPV4, TRPV1/V2, TRPM2) and their roles in glioma.

Main Results:

Certain TRP channels (TRPC6, TRPM8, TRPV4, TRPV1/V2) are associated with glioma patient overall survival.
TRP channels modulate glioma progression through Ca2+ permeability and kinase function, impacting miRNA and signaling cascades.
TRPC6 is implicated in GBM growth and invasiveness, TRPV2 in proliferation and stem cell differentiation, and TRPM2 in chemotherapy delivery.

Conclusions:

TRP channels represent promising biomarkers for glioma diagnosis and prognosis.
Understanding TRP channel mechanisms provides insights into overcoming GBM treatment resistance and recurrence.
Targeting TRP channels offers innovative therapeutic strategies for high-grade gliomas.