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CircRNA EPB41L2 inhibits tumorigenicity of lung adenocarcinoma through regulating CDH4 by miR-211-5p

S-J Zhang1, J Ma, J-C Wu

  • 1Department of Respiratory Medicine, Huaihe Hospital of Henan University, Kaifeng, China.

European Review for Medical and Pharmacological Sciences
|April 30, 2021
PubMed

Insights

This study on lung adenocarcinoma has been withdrawn due to inaccuracies. The research investigated circular RNA EPB41L2

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung adenocarcinoma (LUAD) is a major cause of cancer-related mortality.
  • Circular RNAs (circRNAs) are emerging as critical regulators in various cancers.
  • The role of circRNA EPB41L2 in LUAD tumorigenesis requires further elucidation.

Purpose of the Study:

  • To investigate the function of circRNA EPB41L2 in lung adenocarcinoma.
  • To explore the regulatory mechanism of circRNA EPB41L2 involving miR-211-5p and CDH4.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) to assess gene and microRNA expression.
  • Western blotting to detect protein levels.
  • Cell proliferation and migration assays to evaluate tumorigenicity.

Main Results:

  • CircRNA EPB41L2 was found to be downregulated in LUAD tissues.
  • Overexpression of circRNA EPB41L2 suppressed LUAD cell proliferation and migration.
  • CircRNA EPB41L2 acted as a sponge for miR-211-5p, thereby regulating CDH4 expression.

Conclusions:

  • CircRNA EPB41L2 functions as a tumor suppressor in lung adenocarcinoma.
  • The circRNA EPB41L2/miR-211-5p/CDH4 axis represents a potential therapeutic target for LUAD.

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