Related Experiment Video
Updated: Nov 7, 2025
09:18
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
9.3K
Synoviolin is not a pathogenic factor for auto-inflammatory diseases
Tatsuaki Matsumoto1, Yuiko Sato2, Tami Kobayashi2
1Department of Orthopedic Surgery, Japan.
Summary
Synoviolin does not treat auto-inflammatory diseases, unlike rheumatoid arthritis (RA). Targeting Synoviolin in a mouse model did not alleviate arthritis or joint destruction, indicating distinct therapeutic strategies are needed.
Area of Science:
- Immunology
- Rheumatology
- Genetics
Background:
- Auto-inflammatory syndromes cause arthritis and joint destruction, mimicking rheumatoid arthritis (RA) but requiring distinct treatments.
- Synoviolin, an E3 ligase, is a potential therapeutic target for RA, but its role in auto-inflammatory diseases is unknown.
Purpose of the Study:
- To investigate the therapeutic potential of targeting Synoviolin in a mouse model of auto-inflammatory disease.
Main Methods:
- Generated a conditional knockout mouse model (hIL-1 cTg/Synoviolin cKO) by crossing hIL-1 cTg mice with Synoviolin flox'd mice.
- Ablated Synoviolin expression in adult mice using pIpC induction of Cre recombinase.
- Assessed the impact of Synoviolin ablation on arthritis and joint destruction in the hIL-1 cTg mouse model.
Main Results:
- Synoviolin ablation did not alleviate arthritis or joint destruction in the hIL-1 cTg mouse model.
- Constitutive IL-1 signaling in hIL-1 cTg mice recapitulates key features of auto-inflammatory syndromes.
- These findings rule out Synoviolin as a therapeutic target for auto-inflammatory diseases.
Conclusions:
- Auto-inflammatory diseases and RA are distinct conditions requiring different therapeutic approaches.
- Synoviolin is not a viable therapeutic target for auto-inflammatory syndromes.
- Further research is needed to identify effective treatments for auto-inflammatory diseases.
Related Concept Videos
01:29Autoimmune Disorders
1.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.0K
01:28Inflammatory Response
14.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
14.5K
01:38Inflammation
57.1K
Overview
57.1K
01:17Gastritis-II: Pathophysiology
806
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
806
01:30Inflammatory Response I: Vascular and Cellular
13.7K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.7K
01:20The JAK-STAT Signaling Pathway
9.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.9K