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DFP-induced elevation of strength-duration threshold in hen peripheral nerve
R J Anderson1, D G Robertson, J D Henderson
1Toxicology Program, School of Public Health, University of Michigan, Ann Arbor.
Neurotoxicology
|January 1, 1988
Summary
Organophosphorus agents can cause delayed neuropathy. This study found elevated strength-duration thresholds in nerves are an early indicator of this condition, even before clinical signs appear.
Area of Science:
- Neuroscience
- Toxicology
- Biochemistry
Background:
- Organophosphorus agents are known to induce delayed neuropathy.
- Previous research links delayed neuropathy to elevated strength-duration thresholds.
Purpose of the Study:
- To investigate the biochemical and electrophysiological effects of diisopropylflourophosphate (DFP) and phosphonothioc acid, methyl-[2-(dimethylamino)-ethyl]O-ethyl ester (VX).
- To further establish the correlation between strength-duration changes and organophosphorus-induced delayed neuropathy.
Main Methods:
- Electrophysiological and biochemical analyses were performed on DFP- and VX-treated hens.
- Strength-duration curves, nerve conduction velocity, and acetylcholinesterase activity were measured.
Main Results:
- DFP treatment led to clinical signs of toxicity and significantly elevated strength-duration thresholds in peripheral nerves.
- VX treatment did not cause clinical signs or significant electrophysiological changes, despite reduced acetylcholinesterase activity.
- Creatine phosphokinase activity remained unaffected in both treatment groups.
Conclusions:
- Elevated strength-duration thresholds in peripheral nerves are an early indicator of organophosphorus-induced delayed neuropathy.
- VX does not appear to induce delayed neuropathy despite its anticholinesterase activity.