Increased serum asprosin is correlated with diabetic nephropathy
Rui Wang1, Peng Lin2, Huibo Sun3
1Department of Blood Transfusion, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, People's Republic of China.
Diabetology & Metabolic Syndrome
|May 2, 2021
Summary
Serum asprosin levels increase with diabetic nephropathy (DN) progression in type 2 diabetes (T2DM) patients. Higher asprosin is linked to poorer kidney function and increased DN risk.
Area of Science:
- Endocrinology
- Nephrology
- Metabolic Diseases
Background:
- Asprosin is a newly identified adipokine involved in hepatic glucose production.
- Diabetic nephropathy (DN) is a major complication of type 2 diabetes (T2DM).
Purpose of the Study:
- To investigate the association between serum asprosin concentrations and the presence and severity of DN in T2DM patients.
Main Methods:
- A cohort of 212 T2DM patients was analyzed.
- Patients were stratified into three groups (DN0, DN1, DN2) based on urine albumin-to-creatinine ratio (ACR).
Main Results:
- T2DM patients exhibited higher serum asprosin than controls.
- Serum asprosin levels significantly increased with DN severity (DN2 > DN1 > DN0).
- Asprosin positively correlated with DN risk, disease duration, blood pressure, and markers of renal dysfunction (BUN, creatinine, uric acid, ACR), while negatively correlating with estimated glomerular filtration rate (eGFR).
Conclusions:
- Serum asprosin levels rise progressively with DN.
- Asprosin is a potential biomarker for DN progression and renal function in T2DM.
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