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Mouse models for actinic keratoses.

Justin Choi1, Cameron E West2, Youkyung S Roh1

  • 1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Journal of Pharmacological and Toxicological Methods
|May 2, 2021
PubMed
Summary
This summary is machine-generated.

Actinic keratoses (AKs) are premalignant skin lesions from sun damage, common in aging populations. This review aids selecting mouse models for testing new AK treatments.

Keywords:
Actinic keratosisDMBA/TPAMouse modelSkin cancerSquamous cell carcinomaUVB

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Area of Science:

  • Dermatology
  • Oncology
  • Preclinical Research

Background:

  • Actinic keratoses (AKs) are premalignant skin lesions caused by chronic sun exposure.
  • AK prevalence significantly increases in the aging population.
  • Current animal models for AKs include photocarcinogenesis, chemical carcinogens, and gene modulation.

Purpose of the Study:

  • To review current murine models of actinic keratoses.
  • To guide the selection of appropriate mouse models for future research.
  • To facilitate the testing of novel therapeutic agents for AK treatment.

Main Methods:

  • Photodamage models offer comprehensive methods for AK lesion selection.
  • Photodamage models replicate AK pathogenesis with high fidelity.
  • Review of existing literature on AK murine models.

Main Results:

  • Photodamage models are superior in lesion selection and pathogenetic replication.
  • Each AK model type has distinct advantages and limitations.
  • Understanding model strengths is crucial for experimental design.

Conclusions:

  • Photodamage-induced murine models are valuable for AK research.
  • Appropriate model selection enhances the reliability of therapeutic efficacy studies.
  • This review provides a framework for selecting AK mouse models.