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Degradation study on molecules released from laser-based jet injector.

Jan Krizek¹, Barbora Lavickova², Christophe Moser¹

¹School of Engineering, Laboratory of Applied Photonics Devices, Swiss Federal Institute of Technology in Lausanne (EPFL), Station 17, 1015 Lausanne, Switzerland.

International Journal of Pharmaceutics

|May 2, 2021

Summary

This summary is machine-generated.

This study explored laser-based jet injection, a needle-free method. Results show therapeutic molecules like Lidocaine, δ-Aminolevulinic acid, and DNA remain undamaged after laser-induced jet injection.

Keywords:

Degradation Drug delivery Jet injection Laser cavitation Minimally invasive Needle-free injection Optofluidics

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Area of Science:

Biomedical Engineering
Laser Physics
Pharmaceutical Sciences

Background:

Needle-free injection systems are sought for therapeutic delivery.
Laser-based jet injection using optical cavitation is a promising approach.
Assessing molecular integrity during laser-based injection is crucial.

Purpose of the Study:

To investigate potential damage to therapeutic molecules from nanosecond laser pulses in a jet injection device.
To evaluate the efficacy of a 1574 nm laser for generating jets from pure water solutions.
To confirm the structural and functional integrity of model therapeutics post-injection.

Main Methods:

Utilized a compact laser-based jet injection device with a 1574 nm pulsed laser source.
Generated liquid jets via optical cavitation.
Analyzed Lidocaine and δ-Aminolevulinic acid using H1-NMR.
Assessed structural integrity and functional potency of linear and plasmid DNA.

Main Results:

Successfully generated jets from pure water solutions without needing absorbing dyes.
H1-NMR analysis showed no significant degradation of Lidocaine and δ-Aminolevulinic acid.
DNA samples retained structural integrity and functional potency after laser-induced jet injection.

Conclusions:

The developed laser-based jet injection technique shows minimal damage to therapeutic molecules.
This method circumvents the need for dye reformulation, simplifying therapeutic administration.
The findings support further development for potential clinical applications of needle-free drug delivery.