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[Treatment of asthma crises in children with nebulized salbutamol]
I Pin1, O Pincemaille, P S Jouk
1Service de médecine infantile, CHRG, Grenoble, France.
Insights
Nebulized salbutamol effectively treats acute asthma in children. Repeated low doses improve treatment response, showing it
Area of Science:
- Pediatric Pulmonology
- Pharmacology
Context:
- Acute asthma management in children requires effective bronchodilator therapy.
- Salbutamol is a common short-acting beta-agonist used for asthma treatment.
Purpose:
- To evaluate the efficacy and safety of nebulized salbutamol in pediatric patients with acute asthma.
- To determine the optimal dosing strategy for nebulized salbutamol.
Summary:
- Thirty-two children with acute asthma received nebulized salbutamol.
- 75% of treatments were effective: 47% after the initial dose (0.15 mg/kg) and 27% after a second dose (0.05 mg/kg) 45 minutes later.
- 25% of treatments were ineffective or partially effective. Clinical tolerance was good, with only two adverse events.
Impact:
- Nebulized salbutamol is an effective and safe treatment for acute pediatric asthma.
- Repeated administration of low-dose salbutamol shortly after the initial dose enhances treatment response quality.
Abstract:
Thirty-two children were treated with nebulized salbutamol for acute asthma. Seventy-five per cent of the treatments were efficient, either after a first nebulization at 0.15 mg/kg (47% = group I), or after a second nebulization 45 min later, at 0.05 mg/kg (27% = group II). Twenty-five per cent of the treatments (group III) were inefficient or only partly efficient. The clinical tolerance was good except in two children. Group I and II presented differences only for the auscultation score. Children from group I and II were older and had less severe asthma than those from group III. On the basis of this study, nebulized salbutamol appears to be an affective and safe treatment for acute asthma. The repeated administration of low doses, shortly after the first nebulization increases the quality of the response.