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Updated: Nov 7, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection

Seyed Mohammad Ali Hashemi1,2, Marijn Thijssen3, Seyed Younes Hosseini1

  • 1Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.

Archives of Virology
|May 2, 2021
PubMed

Insights

Host genetic variations significantly influence COVID-19 severity. Understanding these genetic factors, like ACE-2 and immune system genes, is crucial for developing effective treatments for coronavirus disease 2019 (COVID-19).

Area of Science:

  • Genetics
  • Virology
  • Immunology

Background:

  • The global SARS-CoV-2 pandemic highlights the urgent need for effective COVID-19 treatments.
  • While vaccines exist, understanding COVID-19 pathogenesis remains incomplete.
  • Both viral and host factors influence COVID-19 outcomes.

Purpose of the Study:

  • To review the role of host genetic variations in SARS-CoV-2 pathogenesis.
  • To highlight specific gene polymorphisms associated with COVID-19 clinical outcomes.

Main Methods:

  • Literature review focusing on genetic polymorphisms and COVID-19.
  • Analysis of studies investigating host factors in SARS-CoV-2 infection.

Main Results:

  • Host genetic background, including variations in ACE-2, TMPRSS2, and immune genes, impacts COVID-19 severity.
  • Polymorphisms in genes like vitamin D receptor and DPP4 may influence disease progression.
  • Genetic factors contribute to individual differences in COVID-19 manifestations.

Conclusions:

  • Host genetics are a critical determinant of COVID-19 outcomes.
  • Targeting host genetic factors could lead to novel therapeutic strategies for COVID-19.
  • Further research into host-pathogen genetic interactions is warranted.

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