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Updated: Nov 7, 2025

Low-input Nucleus Isolation and Multiplexing with Barcoded Antibodies of Mouse Sympathetic Ganglia for Single-nucleus RNA Sequencing
Published on: March 23, 2022
[SARS-CoV-2 infections and the autonomic nervous system]
R Buchhorn1,2,3, C Willaschek1, C Baumann2
1Klinik für Kinder- und Jugendmedizin, Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Deutschland.
Abstract:
Investigations of the heart rate variability (HRV) in an 11-year-old boy with multisystemic inflammation syndrome in children (MIS-C) and a 16-year-old girl with postural orthostatic tachycardia syndrome (POTS) after SARS-CoV‑2 infections are presented. Results: The MIS‑C is characterized by a maximum suppression of the HRV during ECG monitoring on the pediatric intensive care unit. After intravenous administration of immunoglobulins HRV supppression is rapidly reversible. The POTS is characterized by a heart rate increase of more than 40 bpm and the complete collapse of the HRV in the active standing test that can probably explain some chronic problems after SARS-CoV‑2 infections. In the MIS‑C patient we found autoantibodies against receptors of the autonomic nervous system. Summary: The examination of HRV in patients with COVID-19 are initial descriptions,which can enrich our knowledge of the pathophysiology of this new disease.
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