Nasal Sprays Containing Mometasone Furoate for Relief of Post-Adenotonsillectomy Pain in Children: A Prospective

Ozlem Unsal1, Meltem Akpinar1, Gulpembe Bozkurt2

  • 1Department of Otorhinolaryngology Head and Neck Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul, Turkey.

Sisli Etfal Hastanesi Tip Bulteni
|May 3, 2021
PubMed

Insights

Steroid nasal spray applied post-tonsillectomy significantly reduced pain on postoperative day 5. This finding offers a potential new strategy for managing post-tonsillectomy pain in children.

Area of Science:

  • Otolaryngology
  • Pediatric Surgery
  • Pain Management

Background:

  • Adenotonsillectomy is a common pediatric surgery.
  • Post-tonsillectomy pain management remains a clinical challenge.
  • Current strategies lack a universally effective approach.

Purpose of the Study:

  • To evaluate the analgesic efficacy of steroid-containing nasal spray applied to the tonsillar region after tonsillectomy.
  • To investigate a novel method for improving post-operative pain control.

Main Methods:

  • A randomized study involving 82 pediatric patients undergoing tonsillectomy.
  • The study group received steroid nasal spray on tonsillar regions for 5 days post-surgery.
  • Pain was assessed using a visual analog scale and compared between groups.

Main Results:

  • Pain scores decreased over time in both groups.
  • While not significant from 4 hours to day 5, the steroid nasal spray group showed statistically significant pain reduction on postoperative day 5 (p<0.05).

Conclusions:

  • Post-tonsillectomy pain often peaks around day 5 due to wound inflammation.
  • Steroid nasal spray demonstrated clinical significance in reducing this late-phase pain.
  • This intervention may offer an effective solution for managing post-tonsillectomy pain.
Abstract

Related Concept Videos

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
628
Upper Respiratory Drugs: Decongestants01:27

Upper Respiratory Drugs: Decongestants

Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in...
510
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
241
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
447
Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
1.7K
Adrenergic Agonists: Mixed-Action Agents01:28

Adrenergic Agonists: Mixed-Action Agents

Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
1.1K