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Nanoalgosomes: Introducing extracellular vesicles produced by microalgae.

Giorgia Adamo1, David Fierli2, Daniele P Romancino1

  • 1Institute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.

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|May 3, 2021
PubMed
Summary
This summary is machine-generated.

Researchers discovered nanoalgosomes, a novel type of extracellular vesicle (EV) from microalgae. These nanoalgosomes show potential for cross-kingdom communication and offer a sustainable source for biotechnological applications.

Keywords:
EV‐based therapeuticsbiogenic nano‐delivery systemextracellular vesicles of non‐mammalian organismsmicroalgaemicroalgal extracellular vesiclesnanoalgosomes

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Area of Science:

  • Biotechnology
  • Cell Biology
  • Marine Biology

Background:

  • Extracellular vesicles (EVs) mediate communication between cells and organisms.
  • Microalgae are sustainable sources of bioactive compounds for various industries.
  • Existing research highlights the potential of EVs as drug delivery vehicles.

Purpose of the Study:

  • To describe a newly discovered subtype of EVs derived from microalgae, termed nanoalgosomes.
  • To investigate the properties and cross-kingdom communication potential of nanoalgosomes.
  • To highlight the advantages of nanoalgosomes as a scalable and sustainable resource.

Main Methods:

  • Isolation of nanoalgosomes from microalgal cultures (e.g., *Tetraselmis chuii*) using differential ultracentrifugation or tangential flow fractionation.
  • Focusing on nanosized small EVs (sEVs) for isolation.
  • Biochemical and physical characterization of nanoalgosomes.
  • Assessing uptake of nanoalgosomes by mammalian cell lines.

Main Results:

  • Successful isolation and characterization of nanoalgosomes, a novel type of microalgal EV.
  • Demonstration of efficient uptake of nanoalgosomes by mammalian cell lines.
  • Confirmation of cross-kingdom communication potential mediated by these microalgal EVs.

Conclusions:

  • Nanoalgosomes represent a new class of extracellular vesicles originating from microalgae.
  • These vesicles facilitate communication between microalgae and mammalian cells.
  • Microalgae offer a sustainable, scalable, and advantageous source for nanoalgosome production compared to other EV sources.