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Dexamethasone and diclofenac intramuscular mixture injection and risk of death: A case series study

Abdallah Y Naser1, Sami Qadus1, Hassan Alwafi2

  • 1Department of Applied Pharmaceutical Sciences and Clinical Pharmacy Faculty of Pharmacy Isra University Amman Jordan.

Clinical Case Reports
|May 3, 2021
PubMed

Insights

The combination of diclofenac and dexamethasone injections may increase the risk of fatal cardiovascular events. Further research is needed to confirm these safety concerns and investigate potential genetic factors.

Area of Science:

  • Pharmacology
  • Cardiology
  • Genetics

Background:

  • Diclofenac and dexamethasone are commonly used anti-inflammatory drugs.
  • The safety of combining these two medications via injection is not fully established.

Observation:

  • A potential association between the diclofenac-dexamethasone injection mixture and fatal cardiovascular events was observed.
  • This observation highlights a critical safety concern requiring further investigation.

Findings:

  • The study suggests a possible link between the combined injection and serious cardiac outcomes.
  • Genetic factors may play a role in an individual's susceptibility to these adverse events.

Implications:

  • The findings warrant further clinical studies to definitively assess the cardiovascular safety of this injection mixture.
  • Investigating the genetic underpinnings could lead to personalized risk assessment and preventative strategies.

Keywords:
cardiovasculardexamethasonediclofenacmixturesafety

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