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Published on: October 14, 2014
Effect of glucoglycyrrhizin on IgE-mediated immediate hypersensitivity in mice
Mitsuhiko Nose1, Shinsuke Hisaka2, Atsushi Tsuge2
1Department of Pharmacognosy, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, Aichi, 468-8503, Japan. nose@meijo-u.ac.jp.
Abstract:
To evaluate the pharmacological property of glucoglycyrrhizin (GGL), a unique glycoside of glycyrrhetinic acid (GA), we investigated the anti-allergic effect of GGL on IgE-mediated immediate hypersensitivity in mice. GGL exhibited the antiallergic effect against IgE-mediated immediate hypersensitivity. At a dose of 100 mg/kg, GGL exhibited antiallergic activity equivalent to that of glycyrrhizin (GL). Furthermore, the pretreatment with anti-GA monoclonal antibody eliminated the antiallergic action of GGL. These results indicated that GGL may act in the same way as GL in the human body. Its safety should be verified for its use as a drug similar to GL.
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