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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Calciphylaxis: Risk Factors and Histologic Findings in a Case Series From a Tertiary Care Referral Hospital
M J Sánchez-Pujol1, A Docampo Simón1, F Illán Gambín2
1Servicio de Dermatología, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, España.
Actas Dermo-Sifiliograficas
|May 3, 2021
Summary
Calciphylaxis, a rare vascular disease, is often linked to advanced kidney disease and specific metabolic treatments. Sepsis was the most common cause of death in patients studied.
Area of Science:
- Nephrology
- Dermatology
- Vascular Biology
Background:
- Calciphylaxis is a severe condition characterized by vascular calcification and skin necrosis.
- Understanding its risk factors and diagnostic markers is crucial for patient outcomes.
Observation:
- This retrospective study analyzed 16 calciphylaxis cases over 13 years.
- Key patient demographics and comorbidities were recorded, focusing on risk factors and treatment history.
Findings:
- Advanced kidney disease (75%) and treatments for phosphorus/calcium metabolism disorders (75%) were prevalent.
- Anticoagulation, particularly with vitamin-K antagonists (62.5%), was also a significant factor.
- Histologic findings of elastic fiber alterations were present in only 25% of biopsies.
Implications:
- The findings highlight critical risk factors for calciphylaxis, aiding in early identification and management.
- Sepsis emerged as a primary cause of mortality, emphasizing the need for infection prevention strategies.
- Further research into calciphylaxis pathogenesis and improved diagnostic criteria is warranted.
Keywords:
AcenocoumarolAcenocumarolCalcifilaxisCalciphylaxisFactor de riesgoInsuficiencia renalRenal insufficiencyRisk factorsMore Related Videos
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