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Cardiocerebral Infarction: A Single Institutional Series

Lennie Lynn C de Castillo1, Jose Danilo B Diestro2, Cecileen Anne M Tuazon3

  • 1Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila Philippines.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|May 3, 2021
PubMed

Insights

Cardiocerebral infarction (CCI), a rare condition combining acute ischemic stroke and myocardial infarction, presents significant risks. This study highlights CCI

Area of Science:

  • Cardiology and Neurology
  • Cardiovascular and Cerebrovascular Medicine

Background:

  • Cardiocerebral infarction (CCI) is a rare condition involving simultaneous or sequential acute ischemic stroke (AIS) and acute myocardial infarction (AMI).
  • Understanding the clinical profile, management, and outcomes of CCI patients is crucial due to the complexity and severity of this dual event.

Purpose of the Study:

  • To describe the clinical characteristics, management strategies, and treatment outcomes of patients diagnosed with cardiocerebral infarction (CCI).
  • To determine the prevalence of CCI within a defined patient cohort.

Main Methods:

  • A 3-year cross-sectional study involving patients diagnosed with CCI.
  • Data collection included clinical presentation, management interventions, and outcomes.
  • Primary outcomes were all-cause mortality and functional status (modified Rankin Scale) at discharge and 30 days; hemorrhagic events were also recorded.

Main Results:

  • Twenty-nine patients met CCI criteria (0.79% prevalence); 69% had metachronous and 31% synchronous CCI.
  • Patients experienced moderate-to-severe AIS (median NIHSS 16) and high-risk AMI.
  • Mortality was high at 45% (69% cardiovascular deaths), with limited use of reperfusion therapies (14%); 28% experienced hemorrhagic events.

Conclusions:

  • Cardiocerebral infarction is associated with significant morbidity and mortality, characterized by severe neurological and cardiac events.
  • The findings underscore the need for optimized management strategies for CCI patients, given the high rates of cardiovascular death and poor functional outcomes.
Abstract

Keywords:
Acute ischemic strokeAcute myocardial infarctionCardiocerebral infarctionLow-middle-income country

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