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Related Experiment Video

Updated: Nov 7, 2025

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
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Nutrient Drinking Test as Biomarker in Functional Dyspepsia.

Emidio Scarpellini1, Karen Van den Houte1, Jolien Schol1

  • 1Translational Research Center for Gastrointestinal Diseases (TARGID), Department of Chronic diseases and Metabolism, University of Leuven, Leuven, Belgium.

The American Journal of Gastroenterology
|May 4, 2021
PubMed
Summary

The satiety drinking test (SDT) shows promise as a biomarker for functional dyspepsia (FD), reflecting gastric accommodation. Further research is needed to establish its predictive value for treatment outcomes in FD patients.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Biomarker Discovery

Background:

  • Functional dyspepsia (FD) is common and involves complex issues like poor gastric accommodation and hypersensitivity.
  • Drink tests (DT) are explored as potential biomarkers for gastric sensorimotor dysfunction in FD.

Purpose of the Study:

  • To review current knowledge on various drink tests (DT).
  • To assess the potential of DT as biomarkers for functional dyspepsia (FD).

Main Methods:

  • A comprehensive literature search was performed on PubMed and MEDLINE.
  • Included were English language articles, reviews, meta-analyses, case series, and randomized controlled trials.

Main Results:

  • FD patients consistently ingested less volume in DT variants.
  • The slow nutrient (satiety drinking) test (SDT) demonstrated the clearest distinction between healthy individuals and FD patients, correlating with gastric accommodation.
  • SDTs showed concordance with gastric accommodation for pharmacological agents, particularly those with peripheral actions.

Conclusions:

  • The satiety drinking test (SDT) shows potential as a diagnostic biomarker for FD, reflecting gastric accommodation.
  • Further studies are necessary to validate SDT as a predictive biomarker for treatment response in FD.