Commiphoranes K-O, New Terpenoids from Resina Commiphora and Their Anti-Inflammatory Activities
Xiaohua Yang1,2, Daiwei Wang2, Yongming Yan2
1Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
Abstract:
Commiphorane K (1), a new dinorditerpenoid, commiphoranes L-N (2-4), three new germacrane-type sesquiterpenoids, and commiphorane O (5), one new guaiane-type sesquiterpenoid, were isolated from Resina Commiphora. Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X-ray crystallography. Compounds 2-5 were evaluated for their anti-inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)-stimulated production of TNF-α in RAW264.7 cells in a dose-dependent manner.
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