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Related Experiment Video

Updated: Nov 6, 2025

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
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Rewired Pathways and Disrupted Pathway Crosstalk in Schizophrenia Transcriptomes by Multiple Differential

Hui Yu1, Yan Guo1, Jingchun Chen2

  • 1Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.

Genes
|May 5, 2021
PubMed
Summary

This study analyzed brain gene expression in schizophrenia (SCZ), identifying 60 rewired biological pathways and 92 key genes involved in neurotransmitter and immune functions, offering new insights into SCZ pathophysiology.

Keywords:
PSMC6differential co-expressionpathway crosstalkschizophrenia

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Transcriptomic studies in mental disorders, particularly schizophrenia (SCZ), are limited.
  • Gene expression signatures in SCZ remain largely elusive, hindering understanding of its pathophysiology.

Purpose of the Study:

  • To identify disrupted biological pathways and gene co-expression networks in the human brain associated with schizophrenia.
  • To uncover novel gene expression signatures and potential therapeutic targets for SCZ.

Main Methods:

  • Applied three differential co-expression analysis methods to five transcriptomic datasets (RNA-Seq and microarray) from SCZ and control postmortem brain samples.
  • Constructed a pathway crosstalk network to identify inter-pathway interactions and disconnected gene links.

Main Results:

  • Identified 60 rewired pathways in SCZ, predominantly related to neurotransmitter, synapse, immune, and cell adhesion functions.
  • Discovered 92 consistent hub genes across datasets, suggesting complex roles in SCZ.
  • Highlighted "Clostridium neurotoxicity" and "focal adhesion kinase signaling" as highly interacting pathways and identified specific gene pairs with disrupted correlations.

Conclusions:

  • Systematically identified rewired pathways, disrupted pathway crosstalk, and critical genes/gene links in schizophrenia transcriptomes.
  • The findings provide a comprehensive view of molecular alterations in SCZ.
  • Suggests potential for novel diagnostic and therapeutic strategies targeting identified pathways and genes.