Related Experiment Video
Updated: Nov 6, 2025
12:50
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
6.7K
HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases
Fabrizia Bonacina1, Angela Pirillo2,3, Alberico L Catapano1,3
1Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Cells
|May 5, 2021
Summary
High density lipoproteins (HDL) play a crucial role in modulating immune responses beyond their known cardiovascular benefits. HDL-based therapies show promise for managing the inflammatory aspects of immune-related diseases.
Area of Science:
- Immunology
- Cardiovascular Science
- Biochemistry
Background:
- High density lipoproteins (HDL) are recognized for cardiovascular protection but also influence immune-inflammatory responses.
- Altered HDL levels and composition are observed in autoimmune diseases, correlating with disease severity.
Purpose of the Study:
- To explore the role of HDL in immune-inflammatory modulation beyond cholesterol efflux.
- To investigate HDL's potential in treating immune-inflammatory diseases.
Main Methods:
- Review of basic and clinical research evidence.
- Analysis of molecular mechanisms of HDL interaction with endothelial and immune cells.
- Consideration of genetic mutation studies related to HDL.
Main Results:
- HDL modulates the anti-inflammatory potential of endothelial cells.
- HDL influences immune cell signaling by affecting plasma membrane lipid rafts.
- HDL's function extends beyond cholesterol efflux, impacting immune regulation.
Conclusions:
- HDL possesses significant immunomodulatory properties.
- HDL-based therapies represent a promising strategy to reduce the inflammatory burden in immune-inflammatory diseases.
More Related Videos
Related Concept Videos
01:28Inflammatory Response
14.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
14.4K
01:27Psychoneuroimmunology: Cardiovascular Disease
142
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
142
01:30Inflammatory Response I: Vascular and Cellular
13.6K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.6K
01:38Inflammation
57.0K
Overview
57.0K
01:31Lipid-derived Compounds in the Human Body
5.7K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.7K
01:24T Cell Types and Functions
1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K