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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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The translational sciences clinic: From bench to bedside.

Perry Halushka1,2,3, Tammy L Loucks2, Rechelle Paranal2

  • 1Departments of Pharmacology and Medicine, College of Graduate Studies, Medical University of South Carolina, Charleston, SC, USA.

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|May 5, 2021
PubMed
Summary

The Translational Sciences Clinic provides doctoral trainees with crucial clinical exposure, enhancing their understanding of patient diseases. This mentored experience bridges basic science research with clinical application, proving highly rewarding for trainees and mentors.

Keywords:
Clinical exposuresbench to bedsidementored clinical experiencepredoctoral traineesteam-based approach

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Area of Science:

  • Translational Science
  • Medical Education
  • Clinical Research Training

Background:

  • The National Center for Advancing Translational Science (NCATS) aims to accelerate drug development.
  • Predoctoral trainees in translational research often lack clinical exposure.
  • Bridging basic science and clinical practice is essential for effective translational research.

Purpose of the Study:

  • To develop a mentored clinical exposure program for predoctoral translational research trainees.
  • To provide doctoral (PhD) trainees with clinical perspectives on their research diseases.
  • To enhance the translation of basic science discoveries into improved patient care.

Main Methods:

  • Implementation of the Translational Sciences Clinic program.
  • Trainees participated in weekly half-day clinical rotations for one semester.
  • Trainees engaged with patients and clinical mentors, discussing relevant literature.

Main Results:

  • Trainees reported the clinical rotation as a highly rewarding training experience.
  • Clinical mentors expressed enthusiasm for the program.
  • Mentors were willing to participate in future similar training initiatives.

Conclusions:

  • The Translational Sciences Clinic effectively provides valuable clinical exposure for predoctoral trainees.
  • The program successfully connects bench research with clinical realities.
  • This initiative fosters a deeper understanding of translational science and its impact on patient care.