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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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B-cell acute lymphoblastic leukemia-related microRNAs: uncovering their diverse and special roles

Mengqi Lv1,2, Shicong Zhu3, Hongling Peng1,2

  • 1Department of Hematology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.

American Journal of Cancer Research
|May 5, 2021
PubMed

B-cell acute lymphoblastic leukemia (B-ALL) is a common type of hematologic malignancy characterized by the uncontrolled growth of immature B lymphocytes. Genomics, transcriptomics, and proteomics at different levels contribute to early diagnosis and can thereby provide better treatment for cancer. MicroRNAs (miRNAs) are conducive to the diagnosis and treatment of patients with B-ALL. Moreover, evidence suggests that runaway miRNAs and exosomes containing miRNA may be involved in the occurrence of B-ALL, which can then be used as potential biomarkers. This review summarizes the role of miRNAs in the pathogenesis, diagnosis, prognosis, and treatment of B-ALL.

Keywords:
B-cell acute lymphoblastic leukemiaMicroRNAbiomarkerdiagnosisexosometreatment

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