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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: Jun 21, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Transforming a well into a chip: A modular 3D-printed microfluidic chip.

Rossana Rauti¹, Adi Ess², Baptiste Le Roi¹

¹Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.

APL Bioengineering

|May 5, 2021

Summary

A new Insert-Chip device makes Organ-on-a-Chip technology more accessible. This 3D-printed microfluidic tool allows cell co-culture and flow studies within standard lab equipment, simplifying complex biological research.

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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

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Last Updated: Jun 21, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Published on: October 1, 2007

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Area of Science:

Biomedical Engineering
Microfluidics
Cell Biology

Background:

Organ-on-a-Chip (OOC) platforms enable in vivo-like cell interaction studies.
High costs and technical expertise limit OOC accessibility.

Purpose of the Study:

Introduce a novel, accessible microfluidic device, the Insert-Chip.
Demonstrate its utility for co-culturing cells under flow conditions.

Main Methods:

Developed a user-friendly, reusable Insert-Chip using stereolithography 3D printing.
Integrated the Insert-Chip into standard culture systems (well plates, multi-electrode arrays).
Co-cultured endothelial and epithelial cells under flow to validate functionality.

Main Results:

The Insert-Chip successfully facilitated co-culture of endothelial and epithelial cells under flow.
The device overcomes measurement and imaging challenges of traditional OOC platforms.
Demonstrated ease of integration with standard laboratory equipment.

Conclusions:

The Insert-Chip offers a cost-effective and user-friendly alternative to conventional OOC systems.
This microfluidic device enhances the investigation of cell-cell interactions and therapeutic responses.
Promotes broader adoption of OOC technology in biological research.