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Updated: Nov 6, 2025
07:26
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
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Spin coating mediated morphology modulation in self assembly of peptides
Nandini Bhandaru1, Gagandeep Kaur2, Apurva Panjla2
1Center for Nanosciences, Indian Institute of Technology-Kanpur, Kanpur-208016, Uttar Pradesh, India. nandini@hyderabad.bits-pilani.ac.in sverma@iitk.ac.in.
Nanoscale
|May 5, 2021
Summary
Spin coating controls peptide self-assembly, creating diverse nanostructures like fibrils and nanodots. This method offers a new way to engineer peptide materials for various applications.
Area of Science:
- Peptide self-assembly
- Materials science
- Nanotechnology
Background:
- Controlling peptide nanostructure is crucial for applications in medicine and materials science.
- Traditional methods rely on chemical modification of peptide molecules.
Purpose of the Study:
- To investigate spin coating as a method to control peptide self-assembly.
- To explore the relationship between spin coating parameters and resulting peptide morphologies.
Main Methods:
- Utilized spin coating to deposit diphenylalanine-based peptide solutions.
- Varied spinning speed (RPM) and solution concentration (Cp) during deposition.
- Analyzed resulting self-assembled peptide architectures.
Main Results:
- Achieved diverse peptide morphologies (fibrils, globules, nanodots) over large areas.
- Correlated morphology changes to spin dewetting and continuous film formation.
- Demonstrated control over diphenylalanine analogues using spin coating parameters.
Conclusions:
- Spin coating offers a versatile route to engineer peptide self-assembly and nanostructure.
- This approach allows for on-demand creation of complex peptide assemblies.
- Combines molecular functionalization with physical control via spin coating parameters.
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