He Jiankui´s gene-editing experiment and the non-identity problem

Area of Science:

• Bioethics
• Genetics
• Reproductive Ethics

Background:

• Genetic engineering has been discussed for decades, with CRISPR gene editing technologies recently emerging as a safer and more feasible option.
• The first documented human germline genetic modification resulting in live births occurred, conducted by He Jiankui.

Purpose of the Study:

• To analyze He Jiankui's controversial case of human germline genetic modification.
• To examine the ethical implications of gene editing in relation to the non-identity problem in procreative ethics.
• To inform the development of philosophically grounded legislation for gene-editing technologies.

Main Methods:

• Case study analysis of He Jiankui's actions.
• Philosophical examination of the non-identity problem.
• Ethical analysis of CRISPR and human germline modification.

Main Results:

• The He Jiankui case highlights significant ethical challenges in human germline gene editing.
• The non-identity problem presents a complex ethical dilemma for procreative decisions involving genetic modification.
• Current gene-editing practices raise profound questions about future generations and identity.

Conclusions:

• Ethical frameworks must be developed to address the complexities of gene editing and human germline modification.
• A deeper understanding of procreative ethics, particularly the non-identity problem, is crucial for responsible gene-editing governance.
• Further philosophical and ethical deliberation is needed to guide legislation on CRISPR and similar technologies.