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Related Experiment Video

Updated: Nov 6, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Working memory task induced neural activation: A simultaneous PET/fMRI study.

Isabelle Ripp¹, Lara A Wallenwein², Qiong Wu³

¹Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, Germany; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Martinsried, Germany.

|May 5, 2021

Summary

This summary is machine-generated.

Clinical [18F]fluorodeoxyglucose-PET imaging can detect neural activity changes during working memory tasks. This study shows FDG-PET can track cognitive function, supporting protocol development for neuroscience research.

Keywords:

Cognition FDG PET Neuroimaging Positron emission tomography fMRI

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Area of Science:

Neuroimaging
Cognitive Neuroscience

Background:

Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) typically measures steady-state glucose metabolism.
Its potential to capture dynamic neural activity changes during cognitive tasks is less explored.

Purpose of the Study:

To investigate if a standard FDG-PET protocol can detect neural activity associated with working memory (WM) task performance.
To assess the utility of FDG-PET for tracking cognitive function-related neural changes.

Main Methods:

Hybrid PET/MR data from healthy volunteers were analyzed.
FDG-PET images were acquired during rest and a WM task.
Simultaneous functional magnetic resonance imaging (fMRI) was used for comparison.

Main Results:

Relative FDG uptake increased in brain regions associated with WM during task performance compared to baseline.
These metabolically active regions showed partial overlap with fMRI-identified task-related activation areas.
Evidence of WM task-induced neural activation was found using FDG-PET.

Conclusions:

A clinical FDG-PET protocol can identify neural activation linked to working memory tasks.
These findings support the development of specialized FDG-PET protocols for monitoring cognitive processes.
FDG-PET shows promise for tracking neural correlates of cognitive function.