Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.3K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
3.1K
Metastasis02:30

Metastasis

6.0K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.0K
MicroRNAs01:22

MicroRNAs

3.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.3K
MicroRNAs01:22

MicroRNAs

22.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.8K
Types of RNA01:20

Types of RNA

7.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell types.

Research square·2026
Same author

A proteogenomic RNA processing mechanism drives sex differences in meningioma.

Research square·2026
Same author

Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

Nature neuroscience·2026
Same author

Pnky lncRNA secondary structure maps identify functional regions that control neurogenesis in neural stem cells.

Cell reports·2026
Same author

AR and Beyond: ctDNA Maps Resistance Evolution in mCRPC.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Metabolomic profiling and stable isotope tracing of human schwannomas: A novel perspective on tumor biology and radiation response.

Neuro-oncology advances·2026

Related Experiment Video

Updated: Nov 6, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

806

Long noncoding RNAs in cancer metastasis.

S John Liu1,2,3,4, Ha X Dang5,6,7, Daniel A Lim2,4,8

  • 1Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.

Nature Reviews. Cancer
|May 6, 2021
PubMed
Summary

Long noncoding RNAs (lncRNAs) drive cancer metastasis by regulating key steps like cell transition, invasion, and colonization. These lncRNAs offer potential biomarkers for metastatic risk and novel therapeutic targets.

More Related Videos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.6K

Related Experiment Videos

Last Updated: Nov 6, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

806
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.6K

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Metastasis is a primary cause of cancer mortality, involving complex molecular and phenotypic changes in cancer cells.
  • Long noncoding RNAs (lncRNAs) have emerged as critical regulators in the metastatic cascade.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in promoting cancer metastasis.
  • To explore lncRNA functions in epithelial-mesenchymal transition, invasion, migration, and organ colonization.
  • To discuss lncRNA involvement in the tumor microenvironment and potential as therapeutic targets.

Main Methods:

  • Review of existing literature on lncRNAs and cancer metastasis.
  • Analysis of lncRNA mechanisms, including interactions within ribonucleoprotein complexes and nucleic acid entities.
  • Discussion of in vivo studies, mechanistic commonalities (e.g., TGFβ, NF-κB pathways), and controversial findings.

Main Results:

  • lncRNAs actively promote discrete steps of the metastatic cascade.
  • lncRNAs influence the metastatic tumor microenvironment through various molecular interactions.
  • Specific lncRNAs demonstrate potential as biomarkers for metastatic risk and as targets for antisense oligonucleotide therapy.

Conclusions:

  • lncRNAs are key drivers of cancer metastasis with diverse regulatory functions.
  • Understanding lncRNA mechanisms provides insights into metastasis and potential therapeutic strategies.
  • Further research is needed to address controversies and challenges in lncRNA biology for clinical applications.