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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
22.8K
Gut-microbiota-on-a-chip: an enabling field for physiological research
Grissel Trujillo-de Santiago1,2, Matías José Lobo-Zegers1,2, Silvia Lorena Montes-Fonseca3
1Centro de Biotecnología-FEMSA, Tecnológico de Monterrey.
Microphysiological Systems
|May 6, 2021
Summary
Gut-on-chip systems offer a cost-effective way to study the gut microbiota and human cell interactions. These advanced platforms accelerate understanding of gut health and disease prevention.
Area of Science:
- Microbiology
- Biotechnology
- Human Physiology
Background:
- The gut microbiota plays a crucial role in human health.
- Research has traditionally relied on fecal samples and animal models.
- Rapid advancements are needed for detailed analysis of microbiota-host interactions.
Purpose of the Study:
- To review the design and application of gut-on-chip platforms.
- To highlight the recapitulation of microbiota-human cell interactions in vitro.
- To discuss the potential of these systems for advancing gut health research.
Main Methods:
- Utilizing state-of-the-art microfluidics and biomaterials.
- Integrating advanced cell culture and microbiology techniques.
- Employing genetic expression profiling for detailed analysis.
Main Results:
- Development of gut-on-chip platforms that mimic key host-microbiota interactions.
- Successful recreation of the interplay between human microbiota and host tissues in vitro.
- Demonstration of cost-effective and detailed analysis of these complex interactions.
Conclusions:
- Gut-on-chip systems represent a significant advancement in studying the gut microbiota.
- Integration with microfabrication and stem cell technologies will enhance platform complexity.
- These platforms will accelerate knowledge acquisition and disease prevention strategies for gut health.
