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Good biocompatibility of the polyamide hemofilter
D von Herrath1, M Hüfler, K Hartenstein-Koch
1Medizinische Abteilung II, St.-Joseph-Krankenhaus I, Berlin, FRG.
Blood Purification
|January 1, 1988
Summary
Chronic hemofiltration (HF) offers improved patient comfort and stability compared to hemodialysis. Polyamide HF membranes demonstrate excellent biocompatibility, with minimal impact on leukocytes, thrombocytes, and complement factors.
Area of Science:
- Nephrology
- Biomaterials Science
Background:
- Chronic hemofiltration (HF) is a preferred renal replacement therapy for elderly patients with uremia and cardiovascular issues.
- HF provides superior treatment comfort over hemodialysis, with fewer adverse events like hypotension and cramps.
Purpose of the Study:
- To evaluate the biocompatibility of polyamide hemofiltration membranes.
- To determine if membrane material contributes to the enhanced comfort observed in chronic HF.
Main Methods:
- Assessed biocompatibility by monitoring leukocytes, thrombocytes, elastase, C5a, and C3d levels during HF treatments.
- Compared polyamide membranes with polycarbonate membranes regarding elastase changes.
Main Results:
- Leukocyte and thrombocyte counts remained stable during HF sessions.
- Slight elastase increase showed no significant difference between polyamide and polycarbonate membranes.
- Arterial and venous concentrations of C5a and C3d were largely unchanged.
Conclusions:
- Polyamide HF membranes exhibit good biocompatibility, with no adverse effects on key hematologic and complement parameters.
- Improved biocompatibility of polyamide membranes likely contributes to the superior treatment comfort and vascular stability of chronic HF.