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Updated: Nov 6, 2025

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
Published on: February 24, 2021
Adhesion G protein-coupled receptors in glioblastoma
Gabriele Stephan1, Niklas Ravn-Boess1, Dimitris G Placantonakis1,2,3,4,5
1Department of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
Background:
Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma.
Methods:
Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.
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