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Updated: Nov 6, 2025

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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STN-DBS affects language processing differentially in Parkinson's disease: Multiple-case MEG study.

Rasha Hyder1,2, Andreas Højlund1, Mads Jensen1,3

  • 1Center of Functionally Integrative Neuroscience (CFIN), Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Acta Neurologica Scandinavica
|May 7, 2021
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) impacts spoken language processing in Parkinson's disease (PD) patients. Bilateral and right STN-DBS affect verb semantics, while left STN-DBS influences morphosyntax.

Keywords:
Parkinson's diseaseaction verbbilateraldeep brain stimulationlanguagemagnetoencephalographymorphosyntaxunilateral

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Area of Science:

  • Neuroscience
  • Neurolinguistics
  • Biomedical Engineering

Background:

  • Parkinson's disease (PD) affects motor and non-motor functions, including speech and language.
  • Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a common treatment for PD, but its effects on cognitive functions like language are not fully understood.
  • Investigating neural responses during language processing can elucidate the impact of STN-DBS.

Purpose of the Study:

  • To investigate the effects of bilateral and unilateral STN-DBS on neural responses during spoken language processing in PD patients.
  • To examine how STN-DBS influences the processing of action-related verb semantics and morphosyntactic information.
  • To determine if different stimulation parameters (bilateral vs. unilateral) have differential effects on language processing.

Main Methods:

  • Magnetoencephalography (MEG) was used to record neural responses in three PD patients.
  • Patients were studied under four conditions: no STN-DBS, left unilateral STN-DBS, right unilateral STN-DBS, and bilateral STN-DBS.
  • Linguistic contrasts included action vs. abstract verbs and correct vs. incorrect morphosyntactic inflections, presented passively.

Main Results:

  • Bilateral and right unilateral STN-DBS showed significant differences in processing action vs. abstract verbs, with enhanced responses for action verbs compared to the DBS-off state.
  • Left unilateral STN-DBS demonstrated significant differences in morphosyntax processing, showing greater neuromagnetic responses to incorrect inflections than correct ones.
  • These findings indicate dissociable effects of STN-DBS on different aspects of spoken language comprehension.

Conclusions:

  • Unilateral and bilateral STN-DBS have differential impacts on neuromagnetic responses during spoken language processing in PD.
  • Specific linguistic information processing in PD patients is modulated differently by STN-DBS.
  • These results highlight the complexity of STN-DBS effects on cognitive functions beyond motor control.