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Published on: May 9, 2017
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Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an
Kai Herz1,2, Sebastian Mueller1,2, Or Perlman3
1Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany.
Magnetic Resonance in Medicine
|May 7, 2021
Summary
A new standard for Chemical Exchange Saturation Transfer (CEST) protocols, using the open Pulseq format, enables precise definition, sharing, and simulation. This improves reproducibility in multisite Magnetic Resonance Imaging (MRI) studies.
Area of Science:
- Magnetic Resonance Imaging
- Biomedical Engineering
Background:
- The field of Chemical Exchange Saturation Transfer (CEST) is rapidly expanding with new preparation methods.
- Multisite clinical studies necessitate standardized protocols for consistency across different vendors and imaging sites.
Purpose of the Study:
- To introduce a standardized CEST protocol definition using the open Pulseq format.
- To facilitate sharing, simulation, and accurate measurement of CEST preparation schemes.
Main Methods:
- Development of an open database on GitHub for sharing CEST protocols.
- Implementation of an open-source Bloch-McConnell simulation tool for in silico optimization.
- Creation of a hybrid MR sequence compatible with existing readout modules.
Main Results:
- Achieved good agreement between simulations and measurements due to exact CEST preparation period definitions.
- Established consensus on three amide proton transfer-weighted protocols for comparative studies.
- Demonstrated coherent multisite results for a complex CEST method, proving enhanced reproducibility.
Conclusions:
- Pulseq-CEST offers a simple and complete method for standardizing, sharing, simulating, and measuring CEST preparation schemes.
- This approach enhances the reliability and comparability of CEST imaging across different sites and vendors.
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