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ADIPOCYTOKINES LEPTIN AND ADIPONEСTIN AS PREDICTORS OF GENERALIZED PERIODONTITIS ASSOCIATED WITH OBESITY
D Maiborodina1, M Antonenko1, Y Komisarenko1
1Bogomolets National Medical University, Institute of Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.
Georgian Medical News
|May 8, 2021
Summary
Obesity and overweight are linked to imbalances in leptin and adiponectin, hormones that regulate metabolism. This hormonal imbalance may worsen generalized periodontitis and accelerate tooth loss in affected individuals.
Area of Science:
- Endocrinology
- Periodontology
- Metabolic Syndrome
Background:
- Rising global rates of overweight and obesity correlate with increased prevalence of chronic diseases.
- Generalized periodontitis is associated with metabolic disturbances, particularly in obese individuals, leading to rapid periodontal tissue destruction and tooth loss.
Purpose of the Study:
- To investigate alterations in serum leptin and adiponectin levels in patients with generalized periodontitis comorbid with overweight or obesity.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum leptin and adiponectin.
- Venous blood samples from 94 participants (aged 19-35) were analyzed.
- Participants were categorized into three groups: generalized periodontitis with overweight (32), generalized periodontitis with obesity (40), and a healthy control group (22).
Main Results:
- Patients with generalized periodontitis and overweight/obesity exhibited an imbalance in serum adipokines leptin and adiponectin.
- Elevated body mass index (BMI) was associated with increased leptin and decreased adiponectin levels, consistent with existing literature.
- These adipokine level disruptions were more pronounced in the group with generalized periodontitis and obesity.
Conclusions:
- An imbalance in leptin and adiponectin levels is present in patients with generalized periodontitis and overweight/obesity.
- This adipokine dysregulation may promote pro-inflammatory cytokine production, exacerbating periodontal disease progression in these individuals.
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