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Self-assembling peptides as vectors for local drug delivery and tissue engineering applications
Christina Karavasili1, Dimitrios G Fatouros1
1Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.
Advanced Drug Delivery Reviews
|May 9, 2021
Summary
Self-assembling peptides (SAPs) are advanced biomaterials for drug delivery and tissue engineering. Peptide engineering enhances SAPs
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Molecular self-assembly is revolutionizing biomaterials for drug delivery and tissue engineering.
- Self-assembling peptides (SAPs) are highlighted for their biocompatibility and biodegradability.
- Short, water-soluble SAPs offer improved pharmacokinetic (PK) and pharmacodynamic (PD) profiles for topical drug delivery.
Purpose of the Study:
- To review the potential of short and water-soluble self-assembling peptides (SAPs) in drug delivery and tissue engineering.
- To explore how peptide engineering enhances SAP properties for biomedical applications.
Main Methods:
- Review of literature on self-assembling peptides (SAPs) and their applications.
- Analysis of peptide engineering strategies to tailor SAP functionality.
- Discussion of supramolecular structure formation by SAPs.
Main Results:
- SAPs can form diverse supramolecular structures through self-assembly.
- Peptide engineering allows for the incorporation of desired traits into SAP biomaterials.
- Combined self-assembly and engineering expand SAP multifunctionality.
Conclusions:
- Self-assembling peptides (SAPs) are versatile and potent biomaterials for advanced biomedical applications.
- SAPs offer significant potential in local drug delivery and tissue engineering due to their tunable properties.
