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Updated: Nov 6, 2025

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Mechanisms of selective G protein-coupled receptor localization and trafficking
Jennifer M Kunselman1, Joshua Lott2, Manojkumar A Puthenveedu3
1Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Abstract:
The trafficking of G protein-coupled receptors (GPCRs) to different membrane compartments has recently emerged as being a critical determinant of the signaling profiles of activation. GPCRs, which share many structural and functional similarities, also share many mechanisms that traffic them between compartments. This sharing raises the question of how the trafficking of individual GPCRs is selectively regulated. Here, we will discuss recent studies addressing the mechanisms that contribute to selectivity in endocytic and biosynthetic trafficking of GPCRs.
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