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Updated: Nov 6, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

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Estimated Glomerular Filtration Rate as a Predictor of Restenosis After Carotid Stenting Using First-Generation

Altuğ Ösken1, Evliya Akdeniz1,2, Muhammed Keskin1,3

  • 1Department of Cardiology, 111319Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey.

Angiology
|May 10, 2021
PubMed

Insights

Lower baseline estimated glomerular filtration rate (eGFR) significantly increases the risk of in-stent restenosis (ISR) after carotid artery stenting (CAS). Impaired renal function may predict ISR in patients receiving first-generation stents.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Surgery

Background:

  • Carotid artery stenting (CAS) is a common procedure for preventing stroke.
  • In-stent restenosis (ISR) remains a significant complication after CAS.
  • The role of renal function in predicting ISR after CAS is not fully understood.

Purpose of the Study:

  • To evaluate the impact of baseline estimated glomerular filtration rate (eGFR) on clinical and angiographic outcomes.
  • To assess the long-term in-stent restenosis (ISR) rates in patients undergoing elective CAS.
  • To determine if decreased renal function predicts ISR after CAS.

Main Methods:

  • Retrospective analysis of 456 consecutive patients undergoing elective CAS.
  • Final analysis included 405 patients after 3-year follow-up.
  • Patients were divided into three tertiles based on baseline eGFR levels (T1, T2, T3) for comparison.

Main Results:

  • The 3-year ISR rate was 3.7 times higher in the lowest eGFR tertile (T1) compared to the highest (T3).
  • A lower baseline eGFR was significantly associated with an increased ISR rate, even after adjusting for confounders.
  • ISR of 50% was detected in 12% of surviving patients.

Conclusions:

  • Lower baseline eGFR is a significant predictor of increased ISR after CAS.
  • Decreased renal function may be a key factor in ISR development following CAS with first-generation stents.
  • Further research is warranted to explore the mechanisms linking renal function and ISR.

Keywords:
carotid artery stentingcarotid interventionglomerular filtration ratein-stent restenosisrestenosis

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