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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Castleman's disease.

Himanshu Srivastava1, Dulganti Santosh Reddy1, Shreyas N Shah2

  • 1Department of Oral and Maxillofacial Pathology and Microbiology, Aditya Dental College, Beed, Maharashtra, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|May 10, 2021
PubMed
Summary
This summary is machine-generated.

Castleman's disease, a lymph node hyperplasia, can rarely occur in the neck. This case highlights the importance of histological examination for diagnosing this rare submandibular presentation.

Keywords:
Angiolymphoid hyperplasiaCastleman's diseasecervical lymphadenopathy

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Castleman's disease is a lymphoproliferative disorder characterized by lymph node hyperplasia.
  • It typically affects the mediastinum but can present in the cervical region.

Observation:

  • A rare case of Castleman's disease involving the submandibular lymph node in a 75-year-old male is presented.
  • The patient's condition was initially an asymptomatic solitary mass.

Findings:

  • Definitive diagnosis was established solely through histological examination.
  • Castleman's disease presents in solitary and multicentric forms, with distinct clinical features and prognoses.

Implications:

  • Isolated submandibular Castleman's disease is uncommon.
  • Thorough clinical and histological evaluation is crucial to differentiate it from systemic forms and other cervical lymph node pathologies.