Related Experiment Video
Updated: Nov 6, 2025
06:26
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
1.4K
Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems.
Fengxiang Gao1,2, Zhengrong Xiong1,3
1University of Science and Technology of China, Hefei, China.
Frontiers in Chemistry
|May 10, 2021
Summary
Reactive oxygen species (ROS) responsive polymers offer targeted drug delivery, reducing side effects. This review explores their mechanisms and design for advanced biomedical applications.
Area of Science:
- Biomedical Engineering
- Polymer Science
- Drug Delivery Systems
Background:
- Reactive oxygen species (ROS) are crucial for physiological functions but elevated levels at lesion sites disrupt cellular homeostasis, causing disease.
- Traditional chemotherapy agents have limitations, including toxicity to normal cells and lack of targeted delivery.
Purpose of the Study:
- To review recent advancements in ROS-responsive polymer carriers for targeted drug delivery.
- To focus on the chemical mechanisms and molecular design of these polymers for controlled drug release.
- To discuss current challenges and future prospects in the application of ROS-responsive polymers.
Main Methods:
- Literature review of recent progress in ROS-responsive polymer carriers.
- Analysis of chemical mechanisms underlying ROS-responsiveness in polymers.
- Examination of molecular designs for targeted drug delivery and controlled release.
Main Results:
- ROS-responsive polymer carriers enable targeted drug delivery to lesion sites.
- These carriers mitigate toxicity to healthy cells and reduce side effects.
- Controlled drug release mechanisms are enhanced by ROS-responsive polymer formulations.
Conclusions:
- ROS-responsive polymers represent a promising strategy for advanced drug delivery in biomedicine.
- Further research into their chemical mechanisms and molecular design can optimize therapeutic outcomes.
- Addressing current challenges will unlock the full potential of these advanced formulations.
Related Concept Videos
01:20Radical Autoxidation
2.6K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.6K
01:10Radical Chain-Growth Polymerization: Overview
2.9K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.9K
01:10Radical Reactivity: Steric Effects
2.2K
The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
Along with electronic...
2.2K
01:13Olefin Metathesis Polymerization: Overview
2.3K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.3K
01:17Oxidation of Phenols to Quinones
3.8K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
3.8K
02:35Free-Radical Chain Reaction and Polymerization of Alkenes
8.7K
The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.
8.7K