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Asthma phenotypes and endotypes.
Fabio Lm Ricciardolo1, Francesca Bertolini2, Vitina Carriero2
1Unit of Rare Lung Disease, Department of Clinical and Biological Sciences, Severe Asthma Center, San Luigi Gonzaga University Hospital, University of Turin, Turin, Italy - fabioluigimassimo.ricciardolo@unito.it.
Minerva Medica
|May 10, 2021
Summary
This review summarizes recent asthma research, focusing on phenotypes and endotypes. Understanding asthma
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Asthma is a heterogeneous respiratory condition with variable symptoms.
- Asthma classification has evolved through various phenotypes and endotypes since 1947.
Purpose of the Study:
- To systematically review and describe recent advancements in asthma phenotyping and endotyping.
- To synthesize high-quality evidence published in the last decade.
Main Methods:
- Conducted a systematic review of clinical trials and randomized control trials.
- Searched MEDLINE and EMBASE databases for adult asthma studies.
- Followed PRISMA and CASP guidelines for literature analysis.
Main Results:
- Initial search yielded over 15,000 articles; refined to 50 high-quality studies.
- Classified findings into broader phenotypes and detailed endotypes.
- Identified diverse asthma characterizations.
Conclusions:
- Recent literature highlights asthma's complexity, including symptoms, microbiota, comorbidities, and inflammation.
- Understanding precise pathogenic mechanisms is crucial for developing targeted therapies.
- Advances in phenotyping and endotyping pave the way for precision medicine in asthma treatment.
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