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Updated: Nov 6, 2025

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure.

Christopher Pierce¹, Cara Katterman², Jessica Larsen³

¹Department of Chemical and Biomolecular Engineering, Clemson University.

Journal of Visualized Experiments : Jove

|May 10, 2021

Summary

This summary is machine-generated.

Scientists developed a salt-based method to elongate spherical polymersomes (polymeric vesicles) for improved drug delivery. This technique controls nanoparticle shape, enhancing cellular uptake and targeting capabilities in blood vessels.

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Last Updated: Nov 6, 2025

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

Constant Pressure-controlled Extrusion Method for the Preparation of Nano-sized Lipid Vesicles

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Published on: June 22, 2012

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery

Background:

Polymersomes are bilayer vesicles from block copolymers, capable of encapsulating diverse payloads for therapeutic applications.
The spherical morphology of conventional polymersomes limits their cellular uptake and targeted delivery efficacy.
Developing methods to alter polymersome shape is crucial for advancing their therapeutic potential.

Purpose of the Study:

To introduce a novel salt-based method for increasing the aspect ratios of spherical polymersomes.
To demonstrate control over polymersome shape through post-formation dialysis with varying salt concentrations.
To enhance the applicability of polymersomes in drug delivery and nanomedicine.

Main Methods:

Spherical polymersomes composed of poly(ethylene glycol) (PEG)-based block copolymers were synthesized.
A salt-based method involving post-formation dialysis with sodium chloride was employed to induce shape changes.
Salt concentration was systematically varied to achieve desired elongation and control aspect ratios.

Main Results:

The salt-based method successfully elongated spherical polymersomes, increasing their aspect ratios.
Shape control was achieved by modulating sodium chloride concentration during dialysis.
Elongated polymersomes show potential for improved endothelial targeting in larger vasculature.

Conclusions:

A versatile salt-based protocol enables tunable elongation of polymersomes.
Shape modification of polymersomes can enhance their therapeutic targeting and cellular interaction.
This technique expands the utility of polymersomes for advanced drug delivery systems.