Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Rational Hydrogel Design To Improve Brain Modulus Matching For Implantation.
  1. Home
  3. Rational Hydrogel Design To Improve Brain Modulus Matching For Implantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enabling in vivo imaging in low-resource settings: Computed tomography imaging of gold-loaded polymersomes for the detection of glioblastoma.

Bioengineering & translational medicine·2026
Same author

Design and Recruitment for the Comparative Effectiveness of Zolpidem/Trazodone and Cognitive Behavioral Therapy for Insomnia (COZI) Study in Rural Adults.

Behavioral sleep medicine·2026
Same author

Serum protein alterations characterize feline chronic gingivostomatitis: a case-control study of electrophoresis, immunoglobulin, and cytokine profiles.

American journal of veterinary research·2026
Same author

Fast and sensitive detection of targeted gene fusions using frequency minimizers and fuzzy pattern matching with Fuzzion2.

Cell reports methods·2025
Same author

Smart biocomposite hydrogels in action: unraveling the roles of lignin, temperature, and crosslinker on drug release.

RSC advances·2025
Same author

Multisetting evaluation of Watch-PAT in obstructive sleep apnea diagnosis in patients with atrial fibrillation.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2025
Same journal

Re-direction of surface plasmon-coupled emission using metallic nanoparticles.

Materials letters·2026
Same journal

Optimization of the Modular Reinforced Bone Scaffold for Customized Alveolar Bone Defects.

Materials letters·2024
Same journal

Silver nanoparticle-modified melt-blown polypropylene: Antibacterial and antifungal properties and antiviral activity against SARS-CoV-2.

Materials letters·2023
Same journal

Rapid detection of SARS-CoV-2 using graphene-based IoT integrated advanced electrochemical biosensor.

Materials letters·2022
Same journal

Development of a Modular Reinforced Bone Tissue Engineering Scaffold with Enhanced Mechanical Properties.

Materials letters·2022
Same journal

Virus MIP-composites for SARS-CoV-2 detection in the aquatic environment.

Materials letters·2022
See all related articles

Related Experiment Video

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Rational hydrogel design to improve brain modulus matching for implantation.

Molli Garifo1, Keturah Bethel1, Eric M Davis1

  • 1Department of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.

Materials Letters
|May 14, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Researchers developed injectable copolymer hydrogels that form soft brain implants. These materials match brain tissue stiffness, potentially reducing inflammation and rejection for better brain treatments.

Keywords:
HydrogelNeural biomaterialsPoly(N-isopropylacrylamide)Poly(acrylic acid)

More Related Videos

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Related Experiment Videos

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
06:59

Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants

Published on: March 1, 2019

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Polymer Chemistry

Background:

  • The brain's blood-brain barrier poses challenges for drug delivery and treatment.
  • Modulus-mismatched implants can cause adverse tissue reactions and inflammation.
  • Developing biocompatible and injectable materials for brain implantation is critical.

Purpose of the Study:

  • To fabricate injectable copolymer hydrogels for soft brain implants.
  • To tune the properties of these hydrogels by adjusting polymer concentrations.
  • To create implants with mechanical properties similar to brain tissue to minimize rejection.

Main Methods:

  • Synthesized copolymer hydrogels from poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylic acid) (PAA).
  • Investigated the thermoresponsive behavior and injectability of the hydrogels.
  • Characterized the lower critical solution temperature (LCST) and viscosity.
  • Measured the Young's moduli of the fabricated hydrogels.

Main Results:

  • The PNIPAAm-r-PAA hydrogels are injectable and form soft implants above their LCST.
  • Poly(acrylic acid) concentration effectively tunes the LCST and viscosity.
  • Young's moduli ranged from 1-4 kPa, closely matching rat and human brain tissue.
  • The modulus match suggests reduced inflammation and rejection.

Conclusions:

  • PNIPAAm-r-PAA copolymer hydrogels offer a promising injectable and soft implantable solution for brain applications.
  • Tunable properties allow for customization to specific brain tissue characteristics.
  • The close mechanical match to brain tissue holds potential for improved biocompatibility and reduced implant-associated complications.