Related Experiment Video

Updated: Nov 6, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.9K

Structural feature of TRAFs, their related human diseases and therapeutic intervention

Hyun Ho Park1,2

  • 1College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea. xrayleox@cau.ac.kr.

Archives of Pharmacal Research
|May 10, 2021
PubMed

Insights

This review summarizes structural insights into tumor necrosis factor receptor-associated factor (TRAF) interactions and their role in human diseases. It highlights current clinical trends for developing TRAF-targeting drugs.

Area of Science:

  • Molecular Biology
  • Structural Biology
  • Immunology

Background:

  • Tumor necrosis factor receptor-associated factors (TRAFs) are crucial signaling adaptors.
  • Dysfunctional TRAFs and mutations are implicated in various human diseases.
  • Existing research lacks a comprehensive overview of TRAF-receptor interactions and therapeutic strategies.

Purpose of the Study:

  • To systematically review structural information on TRAF-receptor complexes.
  • To consolidate knowledge on TRAF-associated human diseases.
  • To analyze clinical trends in the development of TRAF-targeting drugs.

Main Methods:

  • Literature review of structural biology studies on TRAF-receptor interactions.
  • Review of research on TRAF mutations and associated pathologies.
  • Analysis of clinical trial data for TRAF-targeted therapies.

Main Results:

  • Detailed structural insights into diverse TRAF-receptor binding interfaces.
  • Identification of specific TRAF malfunctions and mutations linked to diseases like cancer and autoimmune disorders.
  • Overview of ongoing and completed clinical trials for TRAF-based therapeutics.

Conclusions:

  • A unified understanding of TRAF-receptor structures is essential for drug development.
  • Targeting TRAFs offers a promising therapeutic avenue for various human diseases.
  • Further research and clinical trials are needed to fully exploit TRAF-targeting strategies.
Keywords:
Innate immunityStructure-based drug designTRAF domainTRAF familyTRAF-associated diseases

More Related Videos

Working with Human Tissues for Translational Cancer Research07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.1K
Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue FACS-RTT to Determine the Cellular Origin of Radioactive Signal12:04

Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue FACS-RTT to Determine the Cellular Origin of Radioactive Signal

Published on: September 10, 2021

2.6K

Related Concept Videos

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
51
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
77
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.3K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.9K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.3K
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
37