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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
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Bioengineered tooth emulation systems for regenerative and pharmacological purposes
P Pagella, A Cordiale, G D Marconi
1nstitute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland. thimios.mitsiadis@zzm.uzh.ch.
European Cells & Materials
|May 10, 2021
Summary
Dental regenerative therapies face challenges due to a lack of complex human dental tissue models. Innovative in vitro systems like bioreactors and organ-on-a-chip devices show promise for advancing dental tissue regeneration and drug testing.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Research
Background:
- Dental pathologies arise from genetic conditions, injuries, caries, and periodontal diseases.
- Current treatments using inert materials fail to fully restore dental tissue physiology.
- Dental mesenchymal stem cells offer potential for tissue regeneration but clinical applications are limited.
Purpose of the Study:
- To review innovative in vitro culture systems for modeling human dental tissues.
- To explore the potential of these systems for dental regeneration.
- To assess their utility in drug testing applications.
Main Methods:
- Focus on in vitro culture systems, specifically bioreactors and "organ-on-a-chip" microfluidic devices.
- Discuss the development of systems that emulate human tooth physiology.
- Review existing literature on modeling complex dental tissues.
Main Results:
- Advanced in vitro systems are crucial for overcoming limitations in dental regenerative therapies.
- Bioreactors and microfluidic devices offer promising platforms for mimicking dental tissue complexity.
- These systems facilitate research into dental tissue regeneration and drug screening.
Conclusions:
- The development of sophisticated in vitro models is essential for advancing dental regenerative medicine.
- Bioreactors and organ-on-a-chip technologies represent key innovations in dental tissue engineering.
- These platforms hold significant potential for future dental regeneration strategies and pharmaceutical testing.
