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Sleep in children with cystic fibrosis: More under the covers

Joel Reiter1,2, Oded Breuer1,2, Malena Cohen-Cymberknoh1,2

  • 1Pediatric Pulmonology, Sleep and Cystic Fibrosis Center, Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.

Pediatric Pulmonology
|May 11, 2021
PubMed

Insights

Children with cystic fibrosis (CF) often experience impaired sleep quality and efficiency, potentially linked to sleep-disordered breathing (SDB) and lung disease severity.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Genetics and Rare Diseases

Background:

  • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organ systems, notably the respiratory and gastrointestinal tracts.
  • Respiratory symptoms like cough and infections, along with malabsorption, can significantly disrupt sleep in affected children.
  • Existing literature highlights the prevalence of sleep issues in pediatric CF patients.

Purpose of the Study:

  • To review and synthesize current research on sleep disturbances in children with Cystic Fibrosis.
  • To explore the relationship between sleep problems, sleep-disordered breathing (SDB), and respiratory health in pediatric CF.
  • To identify gaps in knowledge regarding the impact of sleep disorders on CF outcomes.

Main Methods:

  • Systematic review of existing literature on sleep disturbances in pediatric CF.
  • Analysis of studies reporting on sleep quality, sleep efficiency, and sleep-disordered breathing (SDB).
  • Correlation analysis between sleep parameters, nocturnal hypoxemia, and CF lung disease severity.

Main Results:

  • Children with CF frequently exhibit reduced sleep quality and efficiency.
  • Sleep-disordered breathing (SDB), including nocturnal hypoxemia, is common in this population.
  • A significant association exists between SDB severity and the extent of lung disease in CF patients.

Conclusions:

  • Sleep disturbances, including SDB, are prevalent in children with CF and are linked to respiratory disease severity.
  • Further investigation is required to fully understand the impact of sleep disorders on CF progression.
  • The potential benefits of treating sleep disorders on pulmonary status in pediatric CF warrant additional research.

Keywords:
cystic fibrosispediatricssleep

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