Innovative extraction materials for fiber-in-tube solid phase microextraction: A review

Area of Science:

• Analytical Chemistry
• Separation Science

Background:

• Fiber-in-tube solid-phase microextraction (SPME) is a miniaturized technique for analyzing compounds.
• Direct coupling to High-Performance Liquid Chromatography (HPLC) systems is advantageous for weakly volatile or thermally labile analytes.

Purpose of the Study:

• To review the fundamental theory of fiber-in-tube SPME-HPLC.
• To highlight innovative extraction materials and their applications.

Main Methods:

• Utilizing various capillary materials (fused-silica, copper, stainless steel, PEEK, PTFE).
• Employing neat fibers (Zylon®, silk, Kevlar 29®) or functionalized fibers (stainless steel, basalt, carbon) with selective coatings (aerogels, ILs, PILs, MIPs, LDHs, conducting polymers).

Main Results:

• Demonstrated successful application of diverse fiber-in-tube SPME configurations.
• Showcased the versatility of the technique for environmental and bioanalytical matrices.

Conclusions:

• Fiber-in-tube SPME-HPLC is a powerful on-line analytical tool.
• Advancements in materials science continue to expand its capabilities for complex sample analysis.