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Related Experiment Videos

Intestinal permeability in dermatitis herpetiformis.

C E Griffiths1, I S Menzies, I G Barrison

  • 1Department of Dermatology, St. Mary's Hospital, London.

The Journal of Investigative Dermatology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Patients with dermatitis herpetiformis show abnormal intestinal permeability, likely due to gluten-induced damage, not an inherent defect. This suggests the rash is not solely caused by increased antigen permeation.

Area of Science:

  • Gastroenterology
  • Immunology
  • Dermatology

Background:

  • Dermatitis herpetiformis (DH) is an autoimmune blistering skin condition.
  • Intestinal permeability is often investigated in DH patients.
  • The relationship between gut health and DH requires further clarification.

Purpose of the Study:

  • To investigate intestinal permeability in patients with dermatitis herpetiformis.
  • To correlate intestinal permeability with small intestinal histology.
  • To determine if abnormal permeability is a primary defect or secondary to gluten exposure.

Main Methods:

  • Differential absorption tests using D-xylose and 3-O-methyl-D-glucose.
  • Intestinal permeation studies with lactulose and L-rhamnose.

Related Experiment Videos

  • Comparison of results between DH patients and healthy volunteers, correlated with small intestinal biopsies.

    • Main Results:

    • Abnormal intestinal lactulose permeation and lactulose/rhamnose ratios were observed in DH patients with villous atrophy.
    • DH patients without villous atrophy did not significantly differ from controls.
    • Delayed plasma D-xylose absorption peaks were common in DH patients, regardless of histology.

    Conclusions:

    • Abnormal intestinal permeability in DH is likely a consequence of gluten-induced mucosal damage.
    • The findings suggest it is not an inherent primary defect of the intestine.
    • The skin rash in DH is unlikely to be solely caused by increased intestinal permeation of antigens.