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HLA-C*06:02 allele can influence clinical efficacy of certolizumab pegol?

Annunziata Dattola1, Elisabetta Botti1, Marco Galluzzo2

  • 1Department of Dermatology University of Rome "Tor Vergata" Rome Italy.

Health Science Reports
|May 12, 2021
PubMed
Abstract

No abstract available in PubMed .

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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