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Updated: Nov 6, 2025

Purification of High Yield Extracellular Vesicle Preparations Away from Virus
Published on: September 12, 2019
Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
Andrew M Leidal1, Jayanta Debnath1
1Department of Pathology and Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco CA USA.
Abstract:
Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy-related genes (ATGs) in non-degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.
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