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A twin study of amino acid concentrations in cerebrospinal fluid
L Hagenfeldt1, G Oxenstierna, G Alfredsson
1Department of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden.
Journal of Psychiatric Research
|January 1, 1988
Abstract:
The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influenced by genetic factors. Genetic variation was also shown for serine, alpha-aminobutyrate and leucine. The results were compared with results from a genetic analysis of the amino acids in serum.